I have assigned the file "E:\Tribune.xlsx" to the My Favorites 1 position.
However, I can't seem to depress the 1/F5 key in such a way as to execute the
file.

Specifically, depressing that key and holding it, should execute that file.
The natural follow through would be to have Office Excel 2007 open with the
file loaded.

Any ideas why those key assignments aren't working?

RaXeT