Try Comodo's BOClean, it's free.
[url]http://www.comodo.com/boclean/boclean.html[/url]

Works just fine on Vista. Be sure to right click
the setup/install file and select "Run as Administrator".
After installing you'll need to reboot.

I also suggest that you might want to invest in a better
AV. Avast is fine, but NOD32 is better. It's not free
but it is worth paying for, and they do have a free trial.
[url]www.eset.com[/url]

Let me know if BOClean solved your problem.

-Michael

* drogan88:[color=blue]
> On May 9, 8:58 am, linuxcrazyman
> <linuxcrazy...@discussions.microsoft.com> wrote:[color=green]
>> Last I heard Microsoft was not in the business of making viruses...
>>
>> "drogan88" wrote:[color=darkred]
>>> VISTA has been changing the actual file size of some of my
>>> program .exe files such that they generate Runtime error R6002 and
>>> terminate. For example, cubase.exe has clean install file size of
>>> 10,000,000 bytes. After a few hours or a few days cubase.exe does not
>>> run anymore and has a filesize of 10,000,512 bytes. This also happened
>>> with quicktime.exe and a few other files. I can copy the
>>> original .exes back into the affected directories and the programs run
>>> again but they keep getting changed for some reason. I have turned off
>>> indexing, system restore and almost every other service I can think
>>> of. Any help would be appreciated. This happens on my VISTA Business
>>> partition and also happened once I updated XPSP2 partition with all of
>>> the current microsoft updates. I wonder if it has something to do with
>>> some new updated features in both VISTA and XPSP2 but I dot know.[/color][/color]
>
> You all were right. I had win32:Parite all over my hard drive. I
> cleaned this up and all my programs are running now. Thanks!. I still
> have one problem with the Smitfraud trojan. My anitvirus software
> detects it and neither Avast, SpywareDoctor or Spyware Remover can
> seem to get rid of it. They all run then ask to reboot the computer
> and then run on reboot but cant seem to get rid of the problem. I
> still get random popup iexplorer windows. The core service file cant
> seem to be deleted. There was a winxp Smitfraud utility that wont run
> on Vista. Is there anything that can be recommended?
>
> Thanks again for the help.
>
>[/color]