Actually you can do better than that combo.

For a home user :

Avast Home - turn off unused shields.
Windows Defender
SmartScreen Filter (in IE8)
Run IE8 in Protected Mode and with InPrivate Filtering as the default
(registry entry)
Prevx 3.0 Free
UAC on or in Quiet Mode
Windows Firewall
Set InPrivate Filtering at AUTO or Prompt and use the converted AdBlocker
File.
Windows UpDates ON however set Advanced System Settings - Hardware Tab -
Windows Update Driver Settings - Never Check for Drivers when I connect a
Device (always go to a device makers site and manually look for updated
drivers).

Even more secure would be to use InPrivate Browsing all the time.

The security built into Vista is so integrated that many programs just get
in the way.

Use SuperAntiSpyware and MalwareBytes as Scanners Only, nothing resident.
Though mine has never caught anything except an occasional cookie.

There are other scenarios however this one is extremely tight.

"Randem" <newsgroups@randem.com> wrote in message
news:%23KXp1vT%23JHA.1340@TK2MSFTNGP05.phx.gbl...[color=blue]
> Dump McAfee and get real protection.
>
> AVG 8.5 Free
> SuperAntiSpyware Free
> MalwareBytes Free
>
> --
> Randem Systems
> Your Installation Specialist
> The Top Inno Setup Script Generator
> [url]http://www.randem.com/innoscript.html[/url]
> Disk Read Error Press Ctl+Alt+Del to Restart
> [url]http://www.randem.com/discus/messages/9402/9406.html?1236319938[/url]
>
>
>
> "Patty" <patty@pattyjean.net> wrote in message
> news:A70297FD-D895-485C-A9A8-916829AFBAA2@microsoft.com...[color=green]
>> I'm running Windows Vista 32-bit, and the latest Mcafee antivirus.
>>
>> I got hit with a trojan virus. Now both Internet Explorer 8 and mozilla
>> 3.1.1 will no longer work. Firefox will no longer load at all. IE8 will
>> load 2 copies and both freeze up before brining up my webpage.
>>
>> Any ideas folks?
>>
>> Patty
>>[/color]
>
>[/color]